Liverpool knocked City off the top with a 4-1 win over Cardiff on Saturday, but Guardiola's men can regain pole position on goal difference if they beat Tottenham at Wembley.
Spurs' new ground will have a retractable National Football League pitch to avoid this situation, a luxury that Wembley does not provide.
"I think Mateo will be strong because he has survived, so he can handle anything that happens in life".
Recent history would suggest that Freddie might be eating humble pie on Monday night as Man City head to Tottenham for a massive game and most are expecting the Citizens to claim the three points. "For me, he's one of the best managers and I admire him a lot".
"I think the circumstances of the a year ago, I think the club is not only focused on winning titles or winning games", the former Espanyol and Southampton boss said.
That is ominous for Spurs when you consider City won the two matches between them last season by an aggregate of 7-2.
Taking over relegation-threatened Espanyol on the other side of town in January 2009, Pochettino's first game in charge was a daunting Copa del Rey quarter-final against Guardiola's Barca.
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"We saw the game against Inter Milan in the Champions League and the last game at PSV Eindhoven and they were not worse than their opponents - I'd say they were better", Guardiola told a press conference.
Tottenham Hotspur manager Mauricio Pochettino on this rearranged fixture being the first of five matches in 12 days: "That is not the ideal situation to compete - we have a problem, we create the problem and we need to sort the problem".
"That's why maybe the games against the contenders are becoming so important".
"But the club needs to be all focused in trying to win titles".
But Guardiola is happy to classify Spurs as title contenders and knows the importance of coming away from Wembley with three points. "That is going to happen anywhere".
The Cyprus under 21 worldwide has been in incredible form from the middle of the park for the club's under 23s team, scoring three goals and providing a further three assists in 11 games.
"Today, we spend a lot of energy on many things. They are a young team with a good 'keeper and a good striker so they have everything to be there", he added.
"When I analysed this game, I realised this is the Premier League".
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