Rhys Webb and Dan Biggar, they're missing too, as is Jonathan Davies and Liam Williams.
Wigglesworth is joined among the replacements by fellow Saracens players Jamie George and George Kruis, all of whom will hope to feature against Wales.
But Wales lock Jones had but a brief response when questioned ahead of the match at Twickenham on Saturday.
"Wales played really well against Scotland but it's going to be different on Saturday - they had no expectation on them last Saturday but this week they come full of expectation".
Jones though has no such ideas. "They've got some world-class players now coming off the bench to strengthen that squad".
Only time will tell if the England coach's attempts to undermine Warren Gatland's team by deploying a series of verbal barbs - notably that fly-half Patchell lacks experience to run a major worldwide and lock Jones went too far in berating referee Pascal Gaüzère at the end of Wales' opening win over Scotland - but on the surface all seemed fairly serene as the visitors prepared to try to repeat their memorable 2015 World Cup triumph at Twickenham.
"Following on from the win against Australia in November, it showed we can be in an arm-wrestle, we can hang in there, find a way to win and that is an important habit to have".
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"We're very grateful that he (Eddie Jones) flagged that up - the fact that you be over-zealous and sometimes appear to go outside the spirit of the game". He is going to have [Chris] Robshaw at him, [Owen] Farrell at him, [Danny] Care at him - all guys that have played a lot of Test rugby.
It's these comments about Patchell that have caused so much controversy in the lead up until kick-off.
England welcome Wales to Twickenham for an eagerly-anticipated Six Nations encounter on Saturday.
"It's a massive game any time you play Wales in the Six Nations", said Care. "He's [Patchell's] a good player". The magic now is to blend in players from other clubs, get them all playing the same style of rugby and it's great that they are playing the style that Scarlets are playing but obviously the national team should be stronger.
Lawes added: "We're hunting Wales this week". I allow him to make the decisions.
"Getting after is the wrong word". But I'm not going to fly out of the line and try to make a difference myself. "I knew the team had the potential to do it and we've seen Scarlets do it week in, week out in the Pro14". He said that England got there first and there was no downward pressure from Wales. There are others up there - winning the league with the Scarlets past year, that famous win against Bath a few weeks ago.
"It was quite amusing, we had a couple of Scarlets calls off the top of our heads at the weekend just by accident but we all reacted to them and got through it", he said.
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