Up front Ross Moriarty has recovered from a back injury to take his place at No 8, alongside Josh Navidi and Aaron Shingler.
McGuigan wasn't actually supposed to start that Australia game but got his chance when Stuart Hogg's hip flexor injury prompted a reshuffle of the back three, with Sean Maitland shifting across to cover full-back.
"Nothing changes I am going out to enjoy the moment and express myself on the rugby field within the team structures that we have".
"It is hard to find positives, Wales were superior today and we have a lot of work to do".
"We are well aware this tournament is going to be very hard".
"We went to Murrayfield a year ago with a view of being dominant, which we were for large parts of the game, but a couple of scrums went down, we brought the referee into it, and then some 50-50 calls went against us".
Wales's Steff Evans scores their fourth try.
Given their form, Welsh skipper Jones is expecting a titanic tussle at Principality Stadium.
Russian opposition leader Alexei Navalny says police raided his office
Navalny himself served three jail sentences of 15 days, 25 days and 20 days for organising unauthorised protests a year ago . Several protesters said they were there first and foremost to oppose the government rather than to support Navalny.
"They have a bag of tricks that I am sure they may dip into at some point of the game as well", added the 32-year-old, who is Wales's most capped lock and will be winning his 114th cap.
"The talk within our camp is that we are trying to maintain our attacking rugby however people view the way we play - that's our sole focus".
However, it was Wales who scored first as Ali Price, the Scotland scrum-half, delayed a long pass too long and his opposite number Gareth Davies intercepted and ran 60 yards untouched for the try in the left corner.
Ali Price and Finn Russell form a unsafe half back partnership.
A great kick from deep by Hadleigh Parkes piled pressure on Scotland in their own five-metre line in the final few minutes of the first half, and but for some lucky bounces in the Scots favour, Wales could have made more of that opportunity.
The side is captained by Scarlets star John Barclay, with Hamish Watson and Cornell Du Preez making up the back-row. "It's not so much about bragging rights, I know how much they put into it and how much rugby means to them and to the Wales team". Scotland assistant coach Mike Blair pointed out during the week that November's opposition had sat off in defence and allowed the boys in blue a bit more room than they are expecting during the next seven weeks, which will be dominated by ferocious competition for the ball at source and breakneck line-speed whenever a team tries to go wide.
"Maybe they will bring in elements of the way Scarlets play because of the numbers they have or maybe it will happen naturally on the pitch because of the combinations the guys are so used to from week in, week out at club level".
- Securities Analyst Recommendations: Presidio, Inc. (PSDO), Summit Midstream Partners, LP (SMLP)
- The gross reason you should be careful walking barefoot on the beach
- NVIDIA Corporation (NVDA): Tech Stock Trending Alert
- Google officially closes HTC acquisition deal
- Prepare for a rare celestial trifecta: Super Blue Blood Moon
- "Black Panther" stars tout its diversity and example at LA premiere
- Spanish police discover 4 tonnes of stolen oranges
- Macron expected to join Rihanna on education work in Senegal
- Kate Middleton honors Princess Diana's legacy at children's hospital
- Waymo Buying 'Thousands' of FCA Minivans for Self-Driving Service