Garoppolo's 334 passing yards marked his career high and first 300-yard passing game.
He completed his first pass to wide receiver DeAndre Hopkins and later rushed for 15 yards for a first down. Yates hasn't played in a game since 2015 when he went 2-0 as Houston's starting quarterback. He's also the third quarterback in 49ers history since the merger in 1970 to win his first two road starts with the club, joining Elvis Grbac and Jim Plunkett.
That was the first of five consecutive possessions that ended with a score for the 49ers. Houston opened the scoring on Ka'imi Fairbairn's 55-yard field goal.
Johnson was taken out of the 49ers' lineup following Hopkins' 29-yard touchdown reception from T.J. Yates.
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The former No. 1 overall draft pick finished the first half with three tackles, including one for loss, and two quarterback hits.
-Linebacker Reuben Foster was shaken up after Texans running back Lamar Miller drilled him on a blitz pickup in the second quarter on a third-down play. The Texans later lost QB Tom Savage to a concussion just prior to the intermission. Foster remained down for a minute before jogging off the field.
Brown's absence means the 49ers will call on Zane Beadles potentially line up against Jadeveon Clowney.
Predictably, the Texans were taking a lot of heat on social media for allowing Savage back in the game.
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