Big brother to Eddie Murphy, Charlie died that morning after battling leukemia at a NY hospital.
"Today, I got some bad news", he said.
He is the older brother of Eddie Murphy.
John closed the reflective moment in his show by performing You're Gonna Live Forever in Me.
Charlie Murphy was also an actor, voice artist, and writer.
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Chappelle asked Mayer to conclude their time with a song dedicated to Murphy.
His family said in a statement Wednesday night that their "hearts are heavy with the loss today of our son, brother, father, uncle and friend Charlie". And John, you are a sight for sore eyes'.
The passing of Murphy, who was 57, has been mourned across the entertainment industry. "My respect to his family and thinking of all of you". Don't forget about the voice of Black Jesus in the animated show The Boondocks.
Aside from his collaborations with Chappelle, Charlie also worked with his brother Eddie on his films such as 1989's Harlem Nights, 1995's Vampire in Brooklyn and the 2007 film, Norbit.
He is credited with appearances to air later this year on the TV drama series Power.
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