The Dutch football federation have summoned coach Danny Blind for talks following a 2-0 defeat by Bulgaria that leaves hopes of reaching the 2018 World Cup hanging by a thread.
"But because the sporting results were so disappointing and made our chances of qualification for the World Cup in Russian Federation very hard, we feel that unfortunately we have to say goodbye to him".
Netherlands assistant coach Fred Grim will stand in as caretaker for Tuesday's friendly against Italy in Amsterdam while the KNVB start to look for a new manager.
But De Ligt's dream debut quickly became a nightmare, making two fatal errors in the first 20 minutes before suffering the indignity of being substituted at half time to save further humiliation.
The Netherlands, three-times World Cup runners-up, also failed to qualify for Euro 2016.
"There was a lot wrong", Robben said.
Blind said he "did not baulk" at the hard choice to select de Ligt, said the federation.
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After the match Blind told journalists that the task of qualifying for Russian Federation had become harder and questioned whether he was still the man for the job.
"We have respect for what Danny did for us and for the team during his tenure", KNVB director Jean Paul Decossaux said in a statement.
"The list should include all kinds of names who can each take Dutch football forward", Decossaux said. Now we'll get shit all over us.
"Ronald Koeman is undoubtedly capable, but I know he is under contract with a club". De Telegraaf say Koeman wanted the job three years ago, but was cast aside, and now he's quite happening achieving success with Everton in the Premier League. "Where the Dutch used to be the great thinkers of the game and you'd always see some kind of influence from Louis van Gaal or Johan Cruyff or Rinus Michels before that, there's now an absolute drought of talented coaches in the Netherlands".
He has had two spells as Netherlands coach, taking the team to third place at the 2014 World Cup.
Dutch striker Bas Dost (centre) heads the ball during the World Cup qualifier against Bulgaria.
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